PALLD polyclonal Antibody | BS60777

PALLD polyclonal Antibody | BS60777 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Palladin, also known as PALLD, PNCA1 or SIH002, is a 1,383 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains five immunoglobulin (Ig) -like domains. Expressed as several alternatively spliced isoforms that are found in kidney, prostate, ovary and colon, palladin functions as a cytoskeletal protein that is required both for the organization of the Actin cytoskeleton, as well as for the establishment of proper cell motility, cell adhesion and cell-matrix interactions. Palladin interacts with Eps8, LASP-1 and VASP and may also play a role in cytoskeletal scaffolding and Actin remodeling. In response to DNA damage, palladin is subject to phosphorylation on select serine residues. Defects in the gene encoding palladin may increase genetic susceptibility to pancreatic cancer, strongly suggesting a role for palladin in tumorigenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PALLD polyclonal Antibody detects endogenous levels of PALLD protein.

Molecular Weight: ~ 151 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Palladin; SIH002; Sarcoma antigen NY-SAR-77; PALLD; KIAA0992; CGI-151

Immunogen: A synthetic peptide corresponding to residues in Human PALLD

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk,