PALMD Antibody | 8237

PALMD Antibody | 8237 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Rat: (100%) , Bovine: (93%) , Pig: (93%) , Mouse: (86%)

Immunogen: PALMD antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PALMD.
The immunogen is located within amino acids 460 - 510 of PALMD.

Research Area: Apoptosis, Cancer

Tested Application: E, WB, IHC-P

Application: PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: PALMD antibody is human specific. At least two isoforms are known to exist.

Positive Control 1: Cat. No. 1310 - Human Bladder Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 61 kDa
Observed: 60 kDa

Validation: N/A

Isoform: N/A

Purification: PALMD antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PALMD antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PALMD antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Palmdelphin, C1orf11, FLJ20271, PALML, Paralemnin-like protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1, 2) . While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3) . PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5) . Abnormal genetic alterations in PALMD are observed in many malignant tumors (5) .