PAN2 Antibody (C-term) [APR31439G]

PAN2 Antibody (C-term) [APR31439G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PAN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 860-888 amino acids from the C-terminal region of human PAN2.

Cellular Localisation: Cytoplasm. Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03182, ECO:0000269|PubMed:18625844, ECO:0000269|PubMed:23398456}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}

Molecular Weight: 135368

Clone: Polyclonal

Gene Name: PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}

Gene ID: 9924

Function: Catalytic subunit of the poly (A) -nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly (A) tails of RNA and the activity is stimulated by poly (A) -binding protein (PABP) . PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly (A) tail length regulation.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PAB-dependent poly (A) -specific ribonuclease subunit PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}, hPan2, 31134 {ECO:0000255|HAMAP-Rule:MF_03182}, Inactive ubiquitin carboxyl-terminal hydrolase 52 {ECO:0000255|HAMAP-Rule:MF_03182}, PAB1P-dependent poly (A) -nuclease {ECO:0000255|HAMAP-Rule:MF_03182}, PAN deadenylation complex catalytic subunit 2 {ECO:0000255|HAMAP-Rule:MF_03182}, PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}, KIAA0710, USP52