PARP1 monoclonal Antibody | MB9403

PARP1 monoclonal Antibody | MB9403 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:50-1:100 IHC:1:100-1:500 FC:1:50-1:100

Background: Poly (ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure, and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD (+) to a number of acceptor molecules including chromatin. PARP-1 recognizes DNA strand interruptions and can complex with RNA and negatively regulate transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. Apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent cell death. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly (ADP-ribosyl) ation contributes to the efficient maintenance of genome integrity.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

Specificity: PARP1 monoclonal Antibody detects endogenous levels of PARP1 protein.

Molecular Weight: 113 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PARP-1, ARTD1, ADPRT 1, PARP1, ADPRT, PPOL, ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase), ADP ribosyltransferase, ADP ribosyltransferase diphtheria toxin like 1, ADP ribosyltransferase NAD (+), ADPRT 1, ADPRT, ADPRT1, ARTD1, msPARP, NAD (+) ADP ribosyltransferase 1, NAD (+) ADP-ribosyltransferase 1, pADPRT 1, pADPRT1, PARP 1, PARP, PARP-1, PARP1, PARP1, Poly (ADP ribose) polymerase 1, poly (ADP ribose) polymerase family, member 1, Poly [ADP-ribose] polymerase 1, Poly (ADP ribose) polymerase, poly (ADP ribose) synthetase, poly (ADP ribosyl) transferase, Poly[ADP ribose] synthetase 1, Poly[ADP-ribose] synthase 1, PPOL,

Immunogen: Peptide

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified

Pathway: