PARP3 Polyclonal Antibody | E-AB-40125

PARP3 Polyclonal Antibody | E-AB-40125 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ADP ribosyltransferase (NAD+, poly (ADP ribose), ADP ribosyltransferase diphtheria toxin like 3, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, hPARP 3, hPARP-3, hPARP3, IRT 1, IRT1, NAD(+) ADP ribosyltransferase 3, NAD(+) ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, PARP3, Poly (ADP ribose) polymerase family, member 3, Poly (ADP ribose) synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP ribose] synthetase 3, Poly[ADP-ribose] synthase 3

Application: WB, IHC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant human PARP3 protein

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000, IHC 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 60 kDa

Molecular Weight(Observed): 60 kDa