PASD1 Antibody (Center) [APR31822G]

PASD1 Antibody (Center) [APR31822G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PASD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the Central region of human PASD1.

Cellular Localisation: [Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801)

Molecular Weight: 87428

Clone: Polyclonal

Gene Name: PASD1 (HGNC:20686)

Gene ID: 139135

Function: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801) . Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801) . Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801) .

Summary: Tissue Location: Testis-specific (PubMed:25936801) . Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level) . Testis-specific (PubMed:15162151) Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL) -derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1