PCI-29732 | B2788

PCI-29732 is a selective and irreversible BTK (Bruton’s tyrosine kinase) inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

PCI-29732 is a selective and irreversible BTK (Bruton’s tyrosine kinase) inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

B2788 | PCI-29732 DataSheet

Alternate Name/Synonyms: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Appearance: Beige solid

Formulation:

CAS Number: 330786-25-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁N₅O

Molecular Weight: 371.44

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent BTK inhibitor

MDL Number:

PubChem CID: 22347110

SMILES: C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N

InChi: InChI=1S/C22H21N5O/c23-21-19-20(26-27(16-6-4-5-7-16)22(19)25-14-24-21)15-10-12-18(13-11-15)28-17-8-2-1-3-9-17/h1-3,8-14,16H,4-7H2,(H2,23,24,25)

InChi Key: GMJUPMONHWAZCP-UHFFFAOYSA-N