PCM-1 Antibody (Center) [APR32450G]

PCM-1 Antibody (Center) [APR32450G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PCM-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632-661 amino acids from the Central region of human PCM-1.

Cellular Localisation: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8AV28}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling

Molecular Weight: 228544

Clone: Polyclonal

Gene Name: PCM1

Gene ID: 5108

Function: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179) . Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651) . Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651) . Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310) .

Summary: Tissue Location: Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC, IF

Dilution: IF--1:10~50 WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Pericentriolar material 1 protein, PCM-1, hPCM-1, PCM1