PCP4 Polyclonal Antibody | E-AB-10016

PCP4 Polyclonal Antibody | E-AB-10016 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Brain specific antigen PCP 4, Brain specific polypeptide PEP 19, Brain specific polypeptide PEP19, Brain-specific antigen PCP-4, Brain-specific polypeptide PEP-19, OTTHUMP00000109191, Pcp4, PCP4, PEP19, Purkinje cell protein 4

Application: WB, IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Neuroscience, Signal Transduction

Background: PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human PCP4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 7 kDa

Molecular Weight(Observed): N/A