PD-1/PD-L1 Inhibitor 1 | B1213

PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. Also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows cancers to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.

PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. Also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows cancers to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.

B1213 | PD-1/PD-L1 Inhibitor 1 DataSheet

Alternate Name/Synonyms: (2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1675201-83-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₃NO₅

Molecular Weight: 475.58

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the protein-protein interaction

MDL Number:

PubChem CID: 91663303

SMILES: CC1=C(C=CC=C1COC2=CC(=C(C(=C2)OC)CN3CCCCC3C(=O)O)OC)C4=CC=CC=C4

InChi: InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1

InChi Key: ZBOYJODMIAUJHH-SANMLTNESA-N