PD 153035 Hydrochloride | 1656

An extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 25 pM). Inhibits other purified kinases only at micromolar or higher concentrations.

PD 153035 Hydrochloride is an extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 25 pM).

1656 | PD 153035 Hydrochloride DataSheet

Alternate Name/Synonyms: N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride: AG 1517; NSC-669364; SU 5271

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 153436-54-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄BrN₃O₂.HCl

Molecular Weight: 396.67

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An EGFR inhibitor

MDL Number: MFCD01074805

PubChem CID: 11246488

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl

InChi: InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12) 20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

InChi Key: ZJOKWAWPAPMNIM-UHFFFAOYSA-N