PD1 Detection Set | SD8600

PD1 Detection Set | SD8600 | Gentaur UK, US & Europe Distribution

Host: llama

Reactivity: Human

Homology: N/A

Immunogen: PD-1 antibodies were raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.

Tested Application: E

Application: N/A

Specificity: N/A

Purification: PD-1 Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.

Clonality: Monoclonal

Isotype: sdab

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PD-1 Antibodies are supplied in PBS.

Concentration: Antibody 1 mg/mL

Storage Condition: PD-1 antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Background: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

User Note: Optimal dilutions for each application to be determined by the researcher.