PDCD4 polyclonal Antibody | BS91038

PDCD4 polyclonal Antibody | BS91038 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:20-1:50 IHC:1:50-1:200 FC:1:50-1:100

Background: The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun. 

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PDCD4 polyclonal Antibody detects endogenous levels of PDCD4 protein.

Molecular Weight: 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PDCD4, H731, Death up-regulated gene protein, Dug, H731, Ma3, MGC33046, MGC33047, Neoplastic transformation inhibitor, Neoplastic transformation inhibitor protein, Nuclear antigen H731, Nuclear antigen H731 like, Nuclear antigen H731 like protein, Nuclear antigen H731-like, PDCD 4, Pdcd4, PDCD4, Programmed cell death 4, programmed cell death 4 (neoplastic transformation inhibitor), Programmed cell death protein 4, Protein 197/15a, Protein MA-3, Tis, Topoisomerase-inhibitor suppressed protein,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: