LBD
PDE11A Antibody (N-term) [AMM07034G]
- SKU:
- LBD-AMM07034G
- Availability:
- Usually ships in 5 working days
Description
PDE11A Antibody (N-term) [AMM07034G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from the N-terminal region of human PDE11A.
Cellular Localisation: Cytoplasm, cytosol.
Molecular Weight: 104752
Clone: Polyclonal
Gene Name: PDE11A
Gene ID: 50940
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Summary: Tissue Location: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level) . Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Dual 3', 5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, PDE11A