PDGFR-β (phospho-Y751) polyclonal Antibody | BS5030

PDGFR-β (phospho-Y751) polyclonal Antibody | BS5030 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-PDGFR-β (Y751) polyclonal Antibody detects endogenous levels of PDGFR-β protein only when phosphorylated at Tyr751.

Molecular Weight: ~ 124, 190 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD140b; PDGFRB; PDGFR; PDGFR1; PDGFRβ

Immunogen: Synthetic phosphopeptide derived from human PDGFR-β around the phosphorylation site of Tyrosine 751.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Immune Cell Signaling,Jak Stat ：IL-6 Receptor Signaling,Signaling Pathways Activating p38 MAP Kinase