PDIA6 Antibody (Center K159) [AMM07078G]

PDIA6 Antibody (Center K159) [AMM07078G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This PDIA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the Central region of human PDIA6.

Cellular Localisation: Endoplasmic reticulum lumen. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545)

Molecular Weight: 48121

Clone: Polyclonal

Gene Name: PDIA6

Gene ID: 10130

Function: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115) . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390) . May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390) . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936) .

Summary: Tissue Location: Expressed in platelets (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC, IF

Dilution: IHC-P--1:100 IF--1:100 WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Protein disulfide-isomerase A6, Endoplasmic reticulum protein 5, ER protein 5, ERp5, Protein disulfide isomerase P5, Thioredoxin domain-containing protein 7, PDIA6, ERP5, P5, TXNDC7