Peficitinib | B2474

Peficitinib is a potent JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC₅₀ = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC₅₀s = 124 and 127 nM, respectively).

Peficitinib is a potent JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC₅₀ = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC₅₀s = 124 and 127 nM, respectively).

B2474 | Peficitinib DataSheet

Alternate Name/Synonyms: ASP015K; 4-(((1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; JNJ 54781532; JNJ-54781532

Appearance: Crystalline solid

Formulation:

CAS Number: 944118-01-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂N₄O₂

Molecular Weight: 326.4

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent JAK inhibitor

MDL Number:

PubChem CID: 57928403

SMILES: C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O

InChi: InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,14?,18?

InChi Key: DREIJXJRTLTGJC-JQCLMNFQSA-N