Pemetrexed | B1862

Pemetrexed is a high affinity dihydrofolate reductase (DHFR) inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Inhibits proliferation of cancer cell lines in vitro.

Pemetrexed is a high affinity dihydrofolate reductase (DHFR) inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Inhibits proliferation of cancer cell lines in vitro.

B1862 | Pemetrexed DataSheet

Alternate Name/Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid

Appearance: White solid

Formulation: N/A

CAS Number: 137281-23-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₁N₅O₆

Molecular Weight: 427.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A high affinity dihydrofolate reductase (DHFR) inhibitor

MDL Number: MFCD19105065

PubChem CID: 446556

SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O

InChi: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1

InChi Key: WBXPDJSOTKVWSJ-ZDUSSCGKSA-N