Perforin polyclonal Antibody | BS91051

Perforin polyclonal Antibody | BS91051 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC FC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Specificity: Perforin polyclonal Antibody detects endogenous levels of Perforin protein.

Molecular Weight: 90 kDa, predicted band size 61 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: P1, PFP, PRF1, Cytolysin, FLH2, HPLH2, Lymphocyte pore-forming protein, P1, PERF, perforin 1 (pore forming protein), Perforin 1, Perforin-1, PFP, PGFL, PIGF, PIGF-2, PLGF, Pore forming protein, prf1, SHGC-10760 Antibody

Immunogen: Recombinant protein within Human Perforin aa 300-500.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: