PF-04554878 | 2888

PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. A combination of PF-04554878 and paclitaxel markedly decreases proliferation and increases apoptosis.

PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. A combination of PF-04554878 and paclitaxel markedly decreases proliferation and increases apoptosis.

2888 | PF-04554878 DataSheet

Alternate Name/Synonyms: N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide; Defactinib; VS-6063

Appearance: White solid

Formulation: N/A

CAS Number: 1073154-85-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₁F₃N₈O₃S

Molecular Weight: 510.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Focla adhesion kinase (FAK) inhibitor

MDL Number: N/A

PubChem CID: 25117126

SMILES: CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F

InChi: InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)

InChi Key: FWLMVFUGMHIOAA-UHFFFAOYSA-N