PF-06447475 | 9447

PF-06447475 is a highly potent, selective, brain-permeable, and in vivo active LRRK2 (Leucine rich repeat kinase 2) kinase inhibitor. Could be potentially useful in the treatment of Parkinson’s disease (PD).

PF-06447475 is a highly potent, selective, brain-permeable, and in vivo active LRRK2 (Leucine rich repeat kinase 2) kinase inhibitor. Could be potentially useful in the treatment of Parkinson’s disease (PD).

9447 | PF-06447475 DataSheet

Alternate Name/Synonyms: 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1527473-33-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₅N₅O

Molecular Weight: 305.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A LRRK2 (Leucine rich repeat kinase 2) kinase inhibitor

MDL Number: N/A

PubChem CID: 72706840

SMILES: C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

InChi: InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)

InChi Key: BHTWDJBVZQBRKP-UHFFFAOYSA-N