PF-06840003 | B2218

PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).

PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).

B2218 | PF-06840003 DataSheet

Alternate Name/Synonyms: 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione; EOS 200271

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 198474-05-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₉FN₂O₂

Molecular Weight: 232.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor

MDL Number: N/A

PubChem CID: 23063810

SMILES: C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F

InChi: InChI=1S/C12H9FN2O2/c13-6-1-2-10-7(3-6)9(5-14-10)8-4-11(16)15-12(8)17/h1-3,5,8,14H,4H2,(H,15,16,17)

InChi Key: MXKLDYKORJEOPR-UHFFFAOYSA-N