PHEX Antibody (C-term) [AMM07122G]

PHEX Antibody (C-term) [AMM07122G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein

Molecular Weight: 86474

Clone: Polyclonal

Gene Name: PHEX

Gene ID: 5251

Function: Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein) -derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632) . Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632) . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632) . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525) . Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505) .

Summary: Tissue Location: Specifically expressed in ovary (PubMed:9070861) . Expressed at low levels in kidney (PubMed:9070861)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX