PHF17 Antibody (N-term) [APR31115G]

PHF17 Antibody (N-term) [APR31115G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human PHF17.

Cellular Localisation: Nucleus. Chromosome Cytoplasm Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the ciliary transition zone.

Molecular Weight: 95533

Clone: Polyclonal

Gene Name: JADE1

Gene ID: 79960

Function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767) . Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767) . May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158) . Promotes apoptosis (PubMed:16046545) . May act as a renal tumor suppressor (PubMed:16046545) . Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112) .

Summary: Tissue Location: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level) . Down-regulated in renal cancer cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17