PHF21A Antibody (Center) [APR14241G]

PHF21A Antibody (Center) [APR14241G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PHF21A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-464 amino acids from the Central region of human PHF21A.

Cellular Localisation: Nucleus.

Molecular Weight: 74854

Clone: Polyclonal

Gene Name: PHF21A

Gene ID: 51317

Function: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

Summary: Tissue Location: Highly expressed in brain (PubMed:31649809) . Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle (PubMed:31649809) . Abundantly expressed in fetal brain (PubMed:31649809) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PHD finger protein 21A, BHC80a, BRAF35-HDAC complex protein BHC80, PHF21A, BHC80, KIAA1696