Phorbol-12-myristate 13-acetate (PMA) | 1544

This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter. Inhibits apoptosis induced by the Fas antigen, but induced apoptosis in HL-60 promyelocytic leukemia cells

Phorbol-12-myristate 13-acetate (PMA) is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter.

1544 | Phorbol-12-myristate 13-acetate (PMA) DataSheet

Alternate Name/Synonyms: PMA, 12-O-Tetradecanoylphorbol 13-acetate,TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate

Appearance: White solid

Formulation: N/A

CAS Number: 16561-29-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₆H₅₆O₈

Molecular Weight: 616.83

Cell-Permeable?: Yes

Purity: >99%

Solubilities: DMSO or EtOH

Handling: Protect from light

Country of Origin: USA

Tag Line: A PKC activator

MDL Number: MFCD00036736

PubChem CID: 27924

SMILES: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

InChi: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

InChi Key: PHEDXBVPIONUQT-RGYGYFBISA-N