Phospho-AMPKα1(S485) Polyclonal Antibody | E-AB-68221

Phospho-AMPKα1(S485) Polyclonal Antibody | E-AB-68221 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: PRKAA1, AMPK, AMPKa1

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Background: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding S485 of human PRKAA1

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 64 kDa/65 kDa

Molecular Weight(Observed): 56 kDa