phospho-Androgen Receptor (Ser515) Polyclonal Antibody | BS65726

phospho-Androgen Receptor (Ser515) Polyclonal Antibody | BS65726 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoforms have been described.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: phospho-Androgen Receptor (Ser515) Polyclonal Antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser515.

Molecular Weight: 99kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Androgen Receptor (phospho S515) ; Androgen Receptor (Phospho-Ser515) ; Androgen Receptor (phospho Ser515) ; p-Androgen Receptor (Ser515) ; ANDR_HUMAN; HYSP1; AIS; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) ; AR; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal and bulbar muscular atrophy; TFM. 

Immunogen: KLH conjugated synthesised phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser515 :YP (p-S) PT

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: Nuclear Receptor Signaling,