Phospho-CCND3 (T283) Antibody [APR05329G]

Phospho-CCND3 (T283) Antibody [APR05329G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CCND3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T283 of human CCND3.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 32520

Clone: Polyclonal

Gene Name: CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585}

Gene ID: 896

Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition (PubMed:8114739) . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase (PubMed:8114739) . Hypophosphorylates RB1 in early G (1) phase (PubMed:8114739) . Cyclin D- CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739) . Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892) . Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: G1/S-specific cyclin-D3, CCND3