LBD
Phospho-EIF4E (S209) Antibody [APR32048G]
- SKU:
- LBD-APR32048G
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Description
Phospho-EIF4E (S209) Antibody [APR32048G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Phospho-EIF4E-S209 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S209 of human EIF4E.
Cellular Localisation: Cytoplasm, P-body. Cytoplasm. Cytoplasm, Stress granule. Nucleus Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732) . Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257)
Molecular Weight: 25097
Clone: Polyclonal
Gene Name: EIF4E (HGNC:3287)
Gene ID: 1977
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813) . In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285) . Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity) . Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity) . In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285) . May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB
Dilution: DB--1:500
Synonyms: Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F