Phospho-ERBB3 (Y1289) Antibody [APR05230G]

Phospho-ERBB3 (Y1289) Antibody [APR05230G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.

Cellular Localisation: [Isoform 1]: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 148098

Clone: Polyclonal

Gene Name: ERBB3

Gene ID: 2065

Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) . Involved in the regulation of myeloid cell differentiation (PubMed:27416908) .

Summary: Tissue Location: Epithelial tissues and brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB, WB

Dilution: DB--1:500 WB--1:1000

Synonyms: Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3