Phospho-FLT3(Y589/591) Polyclonal Antibody | E-AB-68171

Phospho-FLT3(Y589/591) Polyclonal Antibody | E-AB-68171 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: FLT3, CD135, FLK-2, FLK2, STK1

Application: WB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Immunology, Signal Transduction

Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 108 kDa/112 kDa

Molecular Weight(Observed): 113 kDa