Phospho-IGF1R(Y1161) Polyclonal Antibody | E-AB-68139

Phospho-IGF1R(Y1161) Polyclonal Antibody | E-AB-68139 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: IGF1R, CD221, IGFIR, IGFR, JTK13

Application: WB, IHC, IF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Developmental Biology, Signal Transduction

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding Y1161 of human IGF1R

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 154 kDa

Molecular Weight(Observed): 95 kDa