Phospho-LRP6 (Thr1479) Polyclonal Antibody | BS65913

Phospho-LRP6 (Thr1479) Polyclonal Antibody | BS65913 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,

Application: FCM,

Application Range: Flow-Cyt=0.2ug/test

Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Phospho-LRP6 (Thr1479) Polyclonal Antibody detects endogenous levels of LRP6 protein only when phosphorylated at Thr1479.

Molecular Weight: 175kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LRP6 (Phospho-Thr1479) ; LRP6 (Phospho-T1479) ; p-LRP6 (Thr1479) ; p-LRP6 (T1479) ; ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG (p-T) YF

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: