Phospho-mouse p21Cip1 (S78) Antibody [APR05336G]

Phospho-mouse p21Cip1 (S78) Antibody [APR05336G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This mouse p21Cip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S78 of mouse p21Cip1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P38936}. Nucleus

Molecular Weight: 17785

Clone: Polyclonal

Gene Name: Cdkn1a

Gene ID: 12575

Function: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex (PubMed:25329316) . Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity) . Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1