Phospho NMDAR2B (Tyr1474) Antibody | A2208

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

A2208 | Phospho NMDAR2B (Tyr1474) Antibody DataSheet

Antibody Target: NMDAR2B

Target Alternative Name: Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NR2B, N-methyl-D-aspartate receptor subunit 3, NR3, hNR3, MRD6, EIEE27, GRIN2B

Tag Line: Rabbit polyclonal antibody to detect phosphorylation of NMDAR2B at Tyr1474 in human, mouse, rat and dog samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Dog,Rat,Mouse,Human

Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human NMDAR2B

Accession #: Q13224

Gene ID: 2904

Appearance: Colorless liquid

Form: Liquid

Concentration: 1 mg/ml

Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide

Purification: Affinity purified

Application: Western Blotting

Positive Control:

Application And Usages: WB (1:500 - 1:1000)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE