Phospho-p53 (Ser15) Antibody | A1806

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.

A1806 | Phospho-p53 (Ser15) Antibody DataSheet

Antibody Target: Phospho-p53 (Ser15)

Target Alternative Name:

Tag Line: Polyclonal antibody to detect endogenous levels of p53 (pSer15) in human, mouse and rat samples.

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Rat, Mouse, Human

Immunogen Sequence: Synthetic peptide corresponding to amino acids near the N-terminus of human p53 (ser15) (ID# BV-Q51).

Accession #: P04637

Gene ID: 7157

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.

Purification: Affinity purified

Application: Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: False

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False