Phospho-PLM (S68) Antibody [AMM02326G]

Phospho-PLM (S68) Antibody [AMM02326G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: M

Specificity: This PLM Antibody is generated from mice immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S68 of mouse PLM.

Cellular Localisation: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}

Molecular Weight: 10323

Clone: Monoclonal

Gene Name: Fxyd1 {ECO:0000312|MGI:MGI:1889273}

Gene ID: 56188

Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na (+) out of the cell and K (+) into the cell (PubMed:15563542, PubMed:18065526) . Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity) . Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation- mediated inhibition of ATP1B1 (PubMed:21454534) . Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:100~500

Synonyms: Phospholemman, FXYD domain-containing ion transport regulator 1, Fxyd1, Plm