Phospho-POLR2A(S5) Polyclonal Antibody | E-AB-68213

Phospho-POLR2A(S5) Polyclonal Antibody | E-AB-68213 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: POLR2A, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, Pol II

Application: WB, IHC, IF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding S5 of human POLR2A

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 63 kDa/217 kDa

Molecular Weight(Observed): 260 kDa