Phospho-STAT6(Y641) Polyclonal Antibody | E-AB-68151

Phospho-STAT6(Y641) Polyclonal Antibody | E-AB-68151 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: D12S1644, IL-4-STAT, STAT6B, STAT6C, STAT6

Application: WB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 74 kDa/81 kDa/94 kDa

Molecular Weight(Observed): 110 kDa