Phospho-Syk（Y352）/ZAP70（Y319） Polyclonal Antibody | E-AB-68166

Phospho-Syk（Y352）/ZAP70（Y319） Polyclonal Antibody | E-AB-68166 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: SYK/ZAP70

Application: WB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: N/A

Background: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. /This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic phosphorylated peptide around Y352 of human Syk (NP_003168.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 69 kDa/72 kDa/35 kDa/55 kDa

Molecular Weight(Observed): 69 kDa