phospho-TNIK (Ser769) Polyclonal Antibody | BS65918

phospho-TNIK (Ser769) Polyclonal Antibody | BS65918 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when over expressed in Phoenix-A cells. TNIK has been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder and skin.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: phospho-TNIK (Ser769) Polyclonal Antibody detects endogenous levels of TNIK protein only when phosphorylated at Ser769.

Molecular Weight: 150kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TNIK (phospho S769) ; p-TNIK (phospho S769) ; TNIK (phospho-Ser769) ; TNIK (phospho-S769) ; p-TNIK (Ser769) ; p-TNIK (S769) ; Traf2 and NCK interacting kinase; 1500031A17RIK; 4831440I19RIK; AI451411; C530008O15Rik; C630040K21RIK; KIAA0551; MGC189819; MGC189859; RGD1561817; TNIK; TNIK_HUMAN; TRAF2 and NCK-interacting protein kinase.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human TNIK around the phosphorylation site of Ser769:EG (p-S) PV

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: