Phospho-TrkA(Y490) Polyclonal Antibody | E-AB-68163

Phospho-TrkA(Y490) Polyclonal Antibody | E-AB-68163 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Application: WB

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Neuroscience

Background: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding Y490 of human TrkA

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 77 kDa/83 kDa/86 kDa/87 kDa

Molecular Weight(Observed): 150 kDa