Phospho-ZAP70(Y493) Polyclonal Antibody | E-AB-68154

Phospho-ZAP70(Y493) Polyclonal Antibody | E-AB-68154 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70

Application: WB, IHC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Immunology, Signal Transduction, Tags and Cell Markers

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:2000-1:5000 IHC 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 35 kDa/55 kDa/69 kDa

Molecular Weight(Observed): 70 kDa