Phospho-ZBTB16 (Y334) Antibody [APR05208G]

Phospho-ZBTB16 (Y334) Antibody [APR05208G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ZBTB16 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y334 of human ZBTB16.

Cellular Localisation: Nucleus. Nucleus, nuclear body

Molecular Weight: 74274

Clone: Polyclonal

Gene Name: ZBTB16

Gene ID: 7704

Function: Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566) . Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654) . May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312) .

Summary: Tissue Location: Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145