Phytosphingosine | 2426

Phytosphingosine is a phospholipid structurally similar to Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities.

Phytosphingosine is a phospholipid structurally similar to Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria.

2426 | Phytosphingosine DataSheet

Alternate Name/Synonyms: 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS

Appearance: White solid

Formulation: N/A

CAS Number: 554-62-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₃₉NO₃

Molecular Weight: 317.51

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: EtOH (~ 2 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An apoptosis inducer

MDL Number: MFCD06804643

PubChem CID: 122121

SMILES: CCCCCCCCCCCCCCC(C(C(CO)N)O)O

InChi: InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1

InChi Key: AERBNCYCJBRYDG-KSZLIROESA-N