Picropodophyllotoxin | 2765

A potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC₅₀ ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC₅₀ = 0.05 - 15 mM. Exhibits antiangiogenic activitiy.

Picropodophyllotoxin is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC₅₀ ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC₅₀ = 0.05 - 15 mM. Exhibits antiangiogenic activitiy.

2765 | Picropodophyllotoxin DataSheet

Alternate Name/Synonyms: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro­-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7­]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; NSC 36407, PPP, Picropodophyllin

Appearance: White solid

Formulation: N/A

CAS Number: 477-47-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₂O₈

Molecular Weight: 414.41

Cell-Permeable?: Y

Purity: ≥97% by TLC

Solubilities: DMSO (~ 40 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent insulin-like growth factor 1 receptor (IGF1R) inhibitor

MDL Number: MFCD01742647

PubChem CID: 72435

SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O

InChi: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1

InChi Key: YJGVMLPVUAXIQN-HAEOHBJNSA-N