PIP5K1B Antibody (N-term) [APR14298G]

PIP5K1B Antibody (N-term) [APR14298G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PIP5K1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PIP5K1B.

Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P70181}. Cell membrane {ECO:0000250|UniProtKB:P70181}. Endomembrane system. Note=Associated with membranes.

Molecular Weight: 61036

Clone: Polyclonal

Gene Name: PIP5K1B (HGNC:8995)

Gene ID: 8395

Function: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns (4) P/PI4P) to form phosphatidylinositol 4, 5- bisphosphate (PtdIns (4, 5) P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity) . PtdIns (4, 5) P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1, 4, 5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3/PIP3) (By similarity) . Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity) .

Summary: Tissue Location: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta, PIP5K1-beta, PtdIns (4) P-5-kinase 1 beta, Phosphatidylinositol 4-phosphate 5-kinase type I beta, PIP5KIbeta, Protein STM-7, Type I phosphatidylinositol 4-phosphate 5-kinase beta, PIP5K1B, STM7