PIP5K2B Antibody (C-term) [APR10826G]

PIP5K2B Antibody (C-term) [APR10826G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PIP5K2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-317 amino acids from the C-terminal region of human PIP5K2B.

Cellular Localisation: Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm Note=Associated with the plasma membrane and the endoplasmic reticulum

Molecular Weight: 47378

Clone: Polyclonal

Gene Name: PIP4K2B (HGNC:8998)

Gene ID: 8396

Function: Participates in the biosynthesis of phosphatidylinositol 4, 5- bisphosphate (PubMed:9038203, PubMed:26774281) . Preferentially utilizes GTP, rather than ATP, for PI (5) P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281) . Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281) . PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns (4, 5) P2 synthesis and insulin-dependent conversion to PtdIns (3, 4, 5) P3 (PubMed:31091439) .

Summary: Tissue Location: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Diphosphoinositide kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PI (5) P 4-kinase type II beta, PIP4KII-beta, PtdIns (5) P-4-kinase isoform 2-beta, PIP4K2B, PIP5K2B