PIPOX polyclonal Antibody | BS61669

PIPOX polyclonal Antibody | BS61669 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: PIPOX (pipecolic acid oxidase), also known as LPIPOX or PSO, is a 390 amino acid protein that localizes to the peroxisome and belongs to the MSOX/MTOX family. Existing as a monomer, PIPOX uses FAD as a cofactor to catalyze the metabolism and subsequent degradation of sarcosine, L-pipecolic acid and L-proline. The gene encoding PIPOX maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PIPOX polyclonal Antibody detects endogenous levels of PIPOX protein.

Molecular Weight: ~ 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Peroxisomal sarcosine oxidase; PSO; L-pipecolate oxidase; L-pipecolic acid oxidase; PIPOX; LPIPOX; PSO

Immunogen: Synthetic peptide, corresponding Human PIPOX.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: